Could sleep problems raise the chance of preterm birth?

pregnant woman having trouble sleeping
Sleep problems may increase a ladies probability of getting a preterm birth, suggest researchers in the College of California, Bay Area.
Researchers in the College of California, Bay Area have found that ladies who’re identified as having sleep problems while pregnant, including insomnia and anti snoring, are in a larger chance of preterm delivery.

Lead author Jennifer Felder, Ph.D., a postdoctoral fellow within the Department of Psychiatry in the College of California, Bay Area (UCSF), conducted the research with senior author Aric Prather, Ph.D., a helper professor of psychiatry, and colleagues. Their findings were printed within the journal Obstetrics &amp Gynecology.

UCSF’s scientific studies are the very first available look around the results of insomnia while pregnant. From several nearly 3 million women, 2,265 women identified as having a sleep problem while pregnant met the inclusion criteria for that study.

The chosen participants were matched to controls without any such proper diagnosis of a sleep problem, but with similar maternal risks for early delivery, for example high bloodstream pressure, smoking while pregnant, or getting an earlier preterm birth.

Dr. Felder explains, “This gave us more confidence our finding of the earlier delivery among women with disordered sleep was truly due to the sleep problem, and never with other variations between women with and without these disorders.”

The big sample size permitted Dr. Felder, Prof. Prather, and team to research the connection between various sleep problems and preterm birth subtypes. For instance, they could compare early and late preterm birth, or early caused deliveries and spontaneous preterm labor.

The brand new study concentrates on sleep problems, for example anti snoring and insomnia, that may cause significant disruption to rest, instead of analyzing the standard sleep changes that have a tendency to occur while pregnant. The authors state that the real prevalence of those disorders remains unclear because sleep problems in women that are pregnant “frequently go undiagnosed.”

Sleep problems bending preterm birth risk

The preterm birth rates are around 10 % within the U . s . States. Identifying women in a greater chance of having a baby early and offering effective treatments might help to prevent preterm birth. Treating sleep problems while pregnant can also be one step within the right direction of reducing preterm birth rate.

Their findings demonstrated that preterm birth prevalence – understood to be having a baby before 37 days of pregnancy – was 14.6 % for sleep-disorder affected women that are pregnant, in contrast to 10.9 % for that matched control group.

In addition, the risk of early preterm birth before 34 days of pregnancy was greater than double for women that are pregnant who’d anti snoring and almost double for women that are pregnant identified as having insomnia.

Outcomes associated with early preterm birth are essential, the authors note, because there’s an elevated chance of severe complications among early preterm deliveries.

The part of women within the dataset with a sleep problem diagnosis was below 1 %, that was an unpredicted result for that team. They suspect that just probably the most severe cases were identified one of the women that are pregnant.

The ladies who’d an analysis of a sleep problem recorded within their permanent medical record probably had more serious presentations. The chances are the prevalence could be much greater if more women were screened for sleep problems while pregnant.Inch

Aric Prather, Ph.D.

Cognitive behavior therapy (CBT) can be a drug-free choice for tackling sleep problems while pregnant. Evidence implies that CBT works well within the general population, and Dr. Felder and collaborators are recruiting participants for that UCSF Research on Expecting Moms and Sleep Therapy (REST) Study to find out whether it’s effective among women that are pregnant, and, consequently, if the therapy will improve birth outcomes.

“What is so exciting relating to this study is the fact that a sleep problem is really a potentially modifiable risk factor,” concludes Dr. Felder.

Caput succedaneum: Signs and symptoms, causes, and outlook

Caput succedaneum pregnancy
Caput succedaneum can often be identified with ultrasound checking.
An infant’s skull is simple and fused as an adult’s. It’s soft and comprised of parts of bone which meet at “suture lines.” These soft bits of the skull will harden and join together because the child ages.

In some instances, however, the newborn could have a buildup of bloody fluid in the scalp overlying negligence the skull that’s born first. This really is known as caput succedaneum or caput for brief.

Additionally to swelling from the scalp, a bruise might be noticeable either around the scalp itself or around the baby’s face based on which part was created first.

Causes and risks

Caput succedaneum is most generally brought on by pressure put on the youngsters mind because it goes through the cervical opening and in to the vaginal area. This pressure is because vaginal wall and uterine pressure and tension.

Another condition known as cephalohematoma also occurs. This differs from caput succedaneum since the fluid that accumulates is frequently much deeper within the scalp and mostly made up of bloodstream from damaged bloodstream vessels.

Cephalohematoma is because pressure in the mother’s pelvic bones around the baby’s skull during delivery and through delivery instruments, for example forceps.

Both conditions don’t always occur because of specific risks but could happen without no reason during birth. Actually, these conditions can, in rare cases, show up while an infant continues to be within the womb.

Both caput succedaneum and cephalohematoma happen to be identified in ultrasound during late pregnancy. Both of these conditions may develop when membranes rupture prematurely, denying the newborn the required cushioning it takes while still within the womb.

Cephalohematomas are also observed when you will find low levels of amniotic fluid present. This problem is known as oligohydramnios.

Certain risks that make developing caput succedaneum include:

  • getting an extended or difficult labor
  • premature rupture of membranes
  • lower levels of amniotic fluid within the uterus
  • delivering an infant the very first time
  • Braxton-Hicks contractions
  • certain fetal positions, for example being mind lower
  • a delivery that needs instruments, for example forceps or perhaps a vacuum

However, once the caput is because vacuum pressure-aided delivery, it is called a chignon and isn’t a real caput succedaneum.

Cephalohematoma is a disorder that is much more generally observed in ladies who are:

  • getting men baby
  • delivering their first baby
  • delivering a sizable baby, which can be too large for that pelvic opening
  • getting a delivery that needs instruments, for example forceps or perhaps a vacuum
  • when the infant were built with a scalp electrode during labor
  • experiencing an extended labor

The problem can also be more prone to come in children whose heads aren’t in a perfect position for delivery.

Signs and symptoms

When a baby comes into the world with caput succedaneum, parents may notice scalp swelling or perhaps an appearance of puffiness immediately after birth. This is probably to look at the very top core mind where the bones meet.

Scalp bruising is yet another possible characteristic of caput. In some instances, facial bruising can also be present.

Infants born having a cephalohematoma may create a scalp bump (not bruise) within times of birth. At occasions the region might be responsive to touch, that is more prevalent if there’s a skull fracture.

Throughout a vaginal delivery, pressure may cause an overlapping within the soft, bony bits of the skull in the suture line. This could provide a cone-like pointed contour around the newborn’s mind. This really is generally known as molding.


Jaundice can cause caput succedaneum.
Caput succedaneum can lead to jaundice.

Most frequently, caput succedaneum resolves by itself without complication. At occasions, however, complications can happen for example:

  • Alopecia: Because of the pressure put on the scalp, a few of the surrounding tissues may die, and hair thinning can happen. Generally, your hair regrows normally, though in some instances this hair thinning could be permanent.
  • Jaundice: Bruising may trouble certain cases. This may lead to an accumulation of bilirubin within the bloodstream in the introduction to red bloodstream cells. This will cause infants to possess a yellow appearance within their skin and also the whites of the eyes.

If severe or untreated, jaundice can result in many further complications. These complications include:

  • brain damage
  • hearing problems
  • athetoid cerebral palsy, a movement disorder
  • abnormal tooth enamel development
  • permanent upward eye gaze
  • dying

In some instances, cephalohematomas may cause complications, for example:

  • skull fracture
  • hardening from the bump
  • infection
  • anemia
  • jaundice (more prevalent compared to caput succedaneum)


Caput succedaneum is frequently identified on physical examination without resorting to additional testing. If there’s a far more concerning issue, doctors may recommend further tests to judge for any more severe problem.

In some instances of cephalohematoma, a skull fracture might be present. Consequently, an X-ray might be transported to assess the bones from the skull.


Caput succedaneum typically resolves without resorting to intervention within a few days following delivery.

When there aren’t any additional injuries or risks factors, a situation of cephalohematoma typically resolves without resorting to intervention within 2 to six days following delivery.

You will find cases where a cephalohematoma causes various other concerning problems, for example infection, which might require medications and surgical treatments. Sometimes, a cephalohematoma may persist and harden, creating a firm bump, which most frequently resolves with time.

Another possible treatment methods are cranial-molding helmet therapy. This process involves a baby putting on a specifically formed helmet for 18 to twenty hrs each day until their mind is molded towards the preferred shape. It’s very rare to want this therapy for any persistent cephalohematoma, however.

Growing chance of drug withdrawal in newborns as US opioid epidemic accelerates

In america, about every 25 minutes a baby comes into the world with indications of drug withdrawal (also referred to as neonatal abstinence syndrome). These may vary from problems with feeding and sleeping to irritability, difficulty in breathing and seizures.

Drug withdrawal is a common complication of opioid exposure within the womb (in utero), but other psychotropic medications may also cause indications of withdrawal – and therefore are more and more being prescribed to women that are pregnant who’re also receiving an opioid.

So a group people researchers based at Brigham and Women’s Hospital and Harvard School Of Medicine, attempted to measure the impact of in utero contact with both psychotropic medications and opioids on number of instances and harshness of neonatal drug withdrawal.

They analysed data from over 200,000 women that are pregnant who have been signed up for the State medicaid programs program – an american government program that will pay for healthcare services – and who received a prescription to have an opioid.

Then they examined whether the chance of neonatal abstinence syndrome was elevated among infants whose moms were also prescribed psychotropic medication.

After taking account of countless factors that may have affected the outcomes (referred to as confounders), the complete risk for neonatal drug withdrawal was substantially greater among women uncovered to opioids and psychotropic medications than among women uncovered to opioids alone.

The complete chance of withdrawal among women uncovered to prescription opioids alone was around 1%. Contact with any single additional psychotropic medication (antidepressants or benzodiazepines or gabapentin) was connected by having an elevated chance of withdrawal. The greatest risk was among women uncovered to gabapentin (11.4%).

There wasn’t any significant rise in risk with atypical antipsychotics (newer kinds of antipsychotic drugs) and Z drugs (act similarly to benzodiazepines to help ease signs and symptoms of insomnia). The seriousness of the withdrawal signs and symptoms also appeared to improve with concurrent contact with psychotropic medications and opioids.

The authors explain that it is really an observational study, so no firm conclusions could be attracted about expected outcomes, plus they outline some limitations that could have introduced bias. However, results continued to be similar after further analyses were transported out, suggesting they’re robust.

“To conclude, our findings claim that among women using prescription opioids while pregnant, co-contact with antidepressants, benzodiazepines, and gabapentin may be connected by having an elevated chance of drug withdrawal within the neonate,” write the authors.

They claim that clinicians “ought to be careful in prescribing these medications together at the end of pregnancy as well as in prescribing psychotropic medications to women with known or suspected illicit opioid use.”

Our findings also imply that it’ll make a difference for neonatologists and pediatricians to re-think treatment protocols for infants born to ladies who were prescribed multiple drugs throughout their pregnancy.”

Inside a linked editorial, Stephen Patrick, Assistant professor of pediatrics and health policy at Vanderbilt College in Tennessee and colleagues say, despite some limitations “these bits of information are essential in targeting prevention efforts and potentially in tailoring management of opioid uncovered infants.”

They explain which use of medicines during pregnancy “must balance the healthiness of mom using the potential effect on unborn childInch and demand more funding for research and prevention, as well as an growth of treatments for affected moms as well as their infants.”

Article: Chance of neonatal drug withdrawal after intrauterine co-contact with opioids and psychotropic medications: cohort study, Krista F Huybrechts et al., BMJ, doi: 10.1136/bmj.j3326, printed 2 August 2017.

Editorial: Prescribing opioids and psychotropic drugs during pregnancy, Stephen W Patrick et al., BMJ, doi: 10.1136/bmj.j3616, printed 2 August 2017.